5/13/2024 0 Comments Daniel schwartz uconnMultifaceted Macrophage Actions in Diseases The New England Immunology Conference 2022 While compelling evidence has indicated the crucial roles played by epigenetic regulators in both normal developmental control and pathogenesis of diseases, our understanding of the full picture is still in its infancy.Ĭapture Macorphage Actions in Diseases Using Novel Single-Cell Transcriptomics-based algorithms To address the unique challenges in large bio-data analyses, we developed additional computational tools empowered by machine learning algorithms and tailored to biological big data mining (invention, patent pending). Notedly, the application of these novel algorithms revealed a hitherto unknown pathogenic foaming program directly associated with the incidence of ASCVD, which enabled the development of a high-performance, proof-of-concept CVD risk prediction model ( Circulation, 2022). Insight, 2019 Mol Cell, 2019, Cell Metabolism, 2022) and immune cell-function guided predictive tools for immunotherapy ( J.E.M., 2021). Our group recently developed new bioinformatics programs that incorporated single-cell transcriptome technology to allow in-depth fine-mapping monocyte/macrophage function under various diseases conditions ( J.C.I. Work from my lab has contributed to the first discovery of miR-150 as a potent regulator for hematopoietic stem cell-derived B-cell formation and function under normal, obese, and cancerous transformation conditions ( PNAS, 2007 Mol Cancer Res, 2013 Sci Report, 2016) and miR-223 as a potent regulator of macrophage polarization ( Circulation, 2012 J.C.I. We have identified several critical regulators in controlling immune lineage determination, cancerous transformation, and their interaction with host tissue cells under chronic stress conditions. My research program focuses on understanding the regulatory mechanisms of immune cells in obesity-induced type 2 diabetes (T2DM) and atherosclerotic cardiovascular diseases (ASCVD). It is the essence of Immunology to capture and harness the actions of immune cells in complex tissue and stress settings is the essence of immunology. Immune cells are often presented with diversified origins/residences and execute multifaceted functions ever-adapting to microenvironmental cues. (Immunology and computational immunology) Research Travel Award, the Graduate School and Office of the Vice President GrantĬlick the link above (Zhou Lab) for more information and meet our members! Research Travel Award, the Graduate School and the Office of the Vice President Grant Travel award, NIH/NIDDK Workshop on microRNA in cellular development and hematopoiesis, Annapolis, Md. Genzyme Fellowship for Postdoctoral Research Women of Innovation 2020 (Research Innovation and Leadership category)Ĭonnecticut Technology Council and Connecticut Center for Advanced TechnoloĬollege of Veterinary Medicine & Biomedical Sciences, Texas A&M University The Connecticut Academy of Science and Engineering Postdoctoral Fellow, Whitehead Institute for Biomedical Research Protein Chemistry and Genetic Engineering College of Life Sciences, Peking University
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5/13/2024 0 Comments Pre k graduation gift ideasThe first book by the duo, When Things Aren't Going Right, Go Leftis a powerful testament to your child's own agency and ability to direct their path. Reynolds. Its message will remind readers of all ages to find the courage to look inside and love themselves exactly as they are. It's a source of inspiration and a momento they'll always look back on with pride.įor key milestones, kids and families love The Reflection in Meby Marc Colagiovanni with illustrations by Peter H. Books are thoughtful place to share a handwritten note from you (and even to have signed by their current teacher!). Books can be a great way to toss a little proverbial confetti, celebrate your graduate, and create a new tradition. Learn how to create educational printables you can sell online with me!Īs an Amazon Associate I earn from qualifying purchases.Graduating from preschool or kindergarten is an exciting feat for young children as they gear up for bigger classrooms and further learning, or maybe even a new school next year.Ĭelebrate their achievements and build excitement around their progress over the past year. Whatever their age or grade, a graduation honors their accomplishments, and it's a milestone that also marks your support and teamwork as a family. Now that the kids are going off to elementary school, it's the perfect time for you to learn a new side hustle. You'll be sure to find something you like!Ĭlick here to see my store on TeachersPayTeachers: Ready to Keep the Summer Learning Going?Ĭheck out this post with TEN DAYS of free summer learning printables. I create fun pre-writing worksheets, Bingo Sheets, sight word printables, and more. I love creating printables for preschoolers, and I have a shop, if you'd like to check it out, it's on TeachersPayTeachers, a lovely source of lesson plans, worksheets, and fun things to do with your littles. They couldn't wait to show everyone in the neighborhood their “experiment”. My children thought it looked like sparkles in the water. The first thing we did was put dyed water in a bottle with some oil, and then we put an Alka Seltzer in it, and watched the oil dance in the water, it was beautiful. This science experiment book is a fun introduction to summer, when you can spend time doing experiments and answering all the “why” questions. She's a science teacher, so I knew the experiments would be awesome. My children's Auntie bought this book for the family for Christmas last year, and sent it with all of the ingredients to do a few of her handpicked favorites. They're just learning to read, they're happy to show whoever they can. Why do you want to celebrate today, and what do you want your gift to do for them? Book Gifts for Preschool Graduationīook gifts are ALWAYS a good idea. Please see my full disclosure policy for more information. That means I may make a commission if you click and buy. Some of the links below are affiliate links. If you can't be there to celebrate with them, a book, activity, or loving card with encouraging words can be JUST what they need right now. It's always important to celebrate the big moments, and preschool graduation is that big moment. Ready to Keep the Summer Learning Going?.Surviving The Summer Slump with Preschoolers. What gift do you give for kindergarten graduation?.What Do You Get a Preschooler For Graduation?. 5/13/2024 0 Comments Old school runescape map posterThis red square can be clicked and moved to quickly move around the world Map. The area shown on the world map is highlighted in a red square. The Overview button, located on the far right-hand side, is used to show a minimap showing the entire Old School RuneScape world. As words are typed, suggested locations are displayed within the Search bar. This is located at the bottom left of the world map, next to the Key button. To search for a location within the world map, the "Search bar" can be used to type-in keywords. At the very bottom of the Key list, you can turn certain markups on and off. This shows where the building (or location) is located on the map. When an entry in the Key list is clicked, yellow circles will flash on the world map. The Key button, basically shows icons describing specific locations within the map, and is located on the left-hand side on the world Map. Once you reached the max/min zoom level, the buttons mathematical symbol (+/-) will turn orange and not be clickable anymore. You can also use the zoom feature with the Mouse wheel. The key interface showing all icons and markups which you may disable The 100% zoom level corresponds to the zoom level of the player's minimap. To obtain a wider or a more detailed view, the map can be magnified accordingly. The Zoom button is used for zooming the current world map view. This feature can be disabled in the 'Key' side panel under Intra-map links.īuttons Zooming A yellow line will then appear and show where they connect. They are displayed as small yellow squares ( ) and can be enabled by hovering over them with the mouse. Intra-map links are lines that shows which areas are connected with each other. Intra-map links The intra-map feature showing the connection between the Falador mine and the Motherlode mine However, some dungeons, such as the Ogre Enclave, the Barrows, and other dungeons visited during quests are not on the map.Ĭlick "Expand" to view the list of locations not displayed on the world map: You can view other dungeons even if the entrance you clicked is not linked to your target dungeon in any way. After doing so, the surface of Gielinor would disappear, and all left on the map is an underworld consisting solely of dungeons. To use this, you can select a Dungeon from a drop down list at the bottom of the map or click on the entrance to a dungeon on the world map. This feature can be disabled in the Key side panel under 'you are here'. While looking at another part of the map, the "You are here" arrow can be left-clicked to reveal the focus option to scroll automatically to the current location. The "You are here" feature shows the location of the player on the map. To move the map around, you must click and drag using the mouse. The world map, once loaded, will show the current location of the player. This should prevent other players from assuming you are not paying attention to them.įeatures Scrolling A portion of the world map, viewed in-game. While the fullscreen map is displayed, your character will appear to be looking at a scroll of parchment, presumably containing a map on it. The dynamic map may also be zoomed, depending on the player's preference. Players can search it using keywords, quickly move from one location to another one, view the "Key" list where all of the icons are explained and can be clicked to reveal all of the locations of the certain icon. ( Note: The fullscreen world map view cannot be accessed during combat or certain other activities.) This version of the map is dynamic. Doing this will change the game screen into the world map view. You can either open the floating map (default left click) or right click the map icon and select fullscreen for the same map in fullscreen mode. To access the world map, the World map button located on the Minimap must be clicked. Use A player viewing the fullscreen world map. 5/13/2024 0 Comments Etco2 capnography(1) Arterial CO2 should be higher than etCO2.This leads to two foundational principles of etCO2:.#3) By the time gas reaches the endotracheal tube, the end-tidal CO2 concentration will be lower than the arterial CO2 tension.#2) As gas flows from this alveolus out of the lung, it will be diluted by dead space gas that will have a lower CO2 concentration (since this dead space gas doesn't absorb CO2 from the blood).
5/13/2024 0 Comments Us white pages reverse lookupIf you want to see the full report, click "View Full Report." Step 3: Enter the location of this person. You may follow the steps below to use it: If you want to verify someone’s identity or check someone's background using their name, you may use People Search. There are three ways to use White Pages Reverse Lookup : people search, reverse phone, and reverse address. This tool can cut time since White Pages Reverse Lookup is accessible on any device like smartphones, laptops, or desktops. This reverse phone lookup tool can access public records of those who decide to keep their identity anonymous on the internet. Using White Pages Reverse Lookup may be convenient when searching for someone's identity. This service lets you look up phone numbers and receive accurate information about people who call you. White Pages Reverse Phone Lookup is a popular web-based reverse phone lookup tool. You'll also discover the difference between White and Yellow Pages and some alternatives. In this article, discover how you can use this tool more conveniently. White Pages Reverse Lookup is a great tool if you are trying to reconnect or connect with someone or do a background check to avoid possible cyberattacks or identity theft. It is one of the most trusted free people search websites. White Pages ranked 2nd in Public Records and Directories category with 20.5 million total visits as of March 2023. This way can be helpful for you who are looking for someone's identity free of charge. White Pages reverse lookup is a method many people use to search for someone using a phone number, home address, or name. 5/12/2024 0 Comments Shoe shelf storageThe steel construction is durable and comes fully assembled, and we found that no shoes fell from the rack when we jostled it-it just wobbled a bit. You can also purchase additional organizers separately and stack them on top of each other to create a larger storage solution. In our testing, we found it had enough space for about eight pairs of shoes when utilizing the space on the floor underneath the bottom shelf. The Mesh Stackable Shoe Shelf from The Container Store has a basic, one-shelf construction, and it’s just a fraction of the price of our best overall pick. Sometimes, a simple, no-frills shoe rack can organize your footwear just as effectively as a more expensive option. You may need to scrub the mesh with a bristled tool to thoroughly clean. Overall, we think this pick is an elevated shoe rack offering high-quality construction and a minimalist look perfect for any space.ĭimensions: 33.8 x 12.5 x 26.1 inches | Capacity: 12 pairs | Material: Steel The arched overhanging handle allows you to move the unit from room to room (although the unit is pretty heavy at 30 pounds). Though the light color shows dirt more quickly, it took very little effort to clean (plus, you can always opt for navy, black, or green instead). This rack is also easy to wipe down, which makes long-term maintenance hassle-free. We also found the steel shelves to be exceedingly durable after six months of use-the quality and appearance remained consistent throughout, and we were fond of how the elegant design complemented our home. We found it extremely easy to set up this shoe rack, noting that no extra tools were required and that it was very user-friendly for any skill level.Īlthough the manufacturer doesn’t outright list the capacity of this shoe rack, we were able to fit 12 pairs without a problem. Its chic design makes it super versatile, as it can be used in an entryway or hall for storage and decor purposes. This three-shelf organizer from Open Spaces is much more than just a stylish shoe rack. We evaluated each rack on its setup, design, stability, ease of cleaning, capacity, and value. To find the best shoe racks, we tested 31 models in our Des Moines lab and in real-world conditions, including benches that double as shoe storage and over-the-door options that maximize every square foot. “If it is by the entry and promotes the habit of removing shoes when you enter the home, it will also lead to a cleaner, more sanitary house by not dragging everything from the bottom of your shoes all around your living spaces.” “Having a shoe rack provides a designated spot so that hopefully you don't have shoes strewn all around the house,” says Brittani Allen, owner of Pinch of Help, a professional home organization service. While functionality is essential, shoe organizers come in a wide range of designs and styles to suit any household’s needs. I received product and compensation for this post, however all the opinions, projects, and plans are my own.Whether in your closet, entryway, or mudroom, a shoe rack will keep your floors clutter-free and make it easy to quickly find your favorite pairs when you’re rushing out the door. *This post was awesomely sponsored by Kreg. I’m sharing the full tutorial over at !Īnd of course, you can get the full tutorial to make boxes (aka drawers) that go hand-in-hand with this cube organizer to become a cute apothecary styled drawer set. An afternoon is all it takes to make this pretty little guy! I think my favorite thing about this simple cube organizer is how easy it is to make (well for a furniture build anyway), and it only requires four 1″x10″x8′ boards and a box of Kreg screws. Granted, I’m likely to move my custom built cube organizer all around the house too…I could place it vertically against a narrow wall as shelf storage, or lay it horizontally on the floor as a shoe cubby, or add legs to make it sideboad and add my DIY Storage Boxes as drawers. My favorite thing about this simple cube organizer is how easy it is to make…and it only requires four boards and a box of Kreg screws! I keep moving them from room to room because I can’t decide where I want it most! I would have bought a second set, but I started thinking it would be nice to have a smaller custom size to fit some of my smaller nooks and crannies. I have a set of store bought cube organizers that I absolutely love. *This post is sponsored by one of my favs…Kreg Tool! Woop woop! 5/12/2024 0 Comments Bottom front teeth translucentNot only will these restorative treatments improve the appearance of your teeth by making them opaque once again, but they will also protect your teeth from tooth decay. However, once the damage has been done, the only way to get rid of translucent teeth is to visit your dentist for restorative treatments. Therefore, preventing enamel erosion by minimizing acidic foods and beverages is often recommended by dentists. Since tooth enamel is not a living structure, it can not be regrown once it has worn away. Due to the fact that people with enamel hypoplasia develop less enamel than normal, they are at an increased risk of developing translucent teeth. Additionally, this condition can also cause white spots, pits, or grooves to form on the enamel as a result of poor development. Enamel HypoplasiaĮnamel hypoplasia is a condition that affects the development of tooth enamel, causing it to be thinner than normal or non-existent in some rare cares. All of these medical conditions can increase the risk of developing translucent teeth. Celiac disease has also been known to affect the development of enamel, causing it to be thinner than normal. Unfortunately, stomach acid is highly corrosive and can damage your enamel when it frequently comes in contact with it. These conditions can include heartburn, acid reflux, morning sickness, bulimia, and any other condition that causes frequent vomiting. There are also certain medical conditions that can pose a threat to your oral health by exposing your teeth to stomach acid on a regular basis. The more acidic your diet, the higher your risk of developing translucent teeth. Acids are known for their ability to erode surfaces, and your tooth enamel is no exception. Since acidic foods and beverages have lower pH concentrations, they can cause the entire pH of your mouth to decrease, making it more acidic. You see, tooth enamel starts to demineralize around a pH of 5.5 or lower. However, since dentin does not extend to the edges of your teeth, the edges only contain enamel, which is why they look translucent as the enamel breaks down.Įnamel erosion can be caused by many things, however some of the most common culprits are are: Acidic DietĬertain foods and beverages pose a threat to your tooth enamel due to their high acid content. When enamel wears down, two things happen: enamel loses its color and the underlying dentin shows through. While enamel is very strong, it can still be worn down over time. Enamel is the outermost layer of your teeth and is responsible for protecting the inner dentin and pulp layers. The simple answer is that your teeth appear to be translucent along the edges because the enamel has eroded away and become very thin. First things first, we need to take a deeper look at why your teeth can go from being completely opaque to translucent along the edges. 5/12/2024 0 Comments Data rescue pc 5 vs recuvaCompare price, features, and reviews of the software side-by-side to make the best choice for your business. Īs with other file recovery programs Recuva works by looking for unreferenced data, but if the operating system has written new data over a deleted file then recovery will often not be possible. StorageCraft Cloud Backup using this comparison chart. As of version 1.5.3 it can also recover files from Ext2, Ext3 and Ext4 file systems of Linux. It is able to recover lost directory structure and automatically renames files when trying to recover two files of the same name. Any device on your PC that stores data (except for your CD/DVD drive) should be supported. The program works on FAT, exFAT and NTFS file systems of Windows. It will undelete files from hard drives, memory cards, etc. Recuva was described by as an "effective tool for undeleting or salvaging files we sent for recycling and deleted, in the past". Preview thumbnails of intact photos can be displayed in grid view mode and in the side bar. Recuva stands out as one of the best video recovery software for offering so many attractions, such as its easy-to-use and clear interface, as well as its. Recuva hasn’t had a major update since 2016. Other data recovery software tools get updates more often, but it’s still way better than Recuva. Recuva can recover files deleted from internal and external hard disk drives, USB flash drives, memory cards, portable media players or all random-access storage mediums with a supported file system. baramundi Management Suite using this comparison chart. MiniTool’s update frequency is pretty average, with Power Data Recovery receiving updates roughly every 6 months. Piriform Recuva is a standalone product of CCleaner, a developer specializing in data recovery and system. It is able to undelete files that have been marked as deleted the operating system marks the areas of the disk in which they were stored as free space. Overview of Recuva Data Recovery Software. Microsoft 365 and Salesforce data, protect against ransomware, improve compliance, and reduce IT costs. Recuva ( / r ɪ ˈ k ʌ v ə/) is an undeletion program for Windows, developed by Piriform Software. Compare price, features, and reviews of the software side-by-side to make the best choice for your business. Including both 32-bit and 64-bit versions, but not RT tablet editions. After downloading, installing, and testing Recuva for data recovery on our computer, we found Recuva to be a safe and reliable program to use. 5/11/2024 0 Comments Diy pvc chicken feeder watererOn the other side of the elbow fitting, mark a half-circle that will serve as the feeding port. This elbow will act as the feeding point for your chickens. If you want a permanent attachment, use PVC cement to secure the elbow in place. Take the 90-degree elbow fitting and attach it to one end of the cut PVC pipe. Use your razor knife or PVC cutter to cut the pipe cleanly at the marked point. Typically, a 4-foot length works well for a standard feeder. Measure and mark your PVC pipe to the desired length. You can also view the images as a slideshow if you prefer Instructions:
5/11/2024 0 Comments Richard nason finch pruynConstruction:Īs the most populous metropolitan area in the United States, New York City is partly known for the ever-changing nature of its skyline. In addition to the naturally occurring deposits within the state, asbestos can also be found intermingled with other mineral deposits like talc, increasing the risk of exposure for miners and others who work with the extracted materials. In areas of Upstate New York near the border of Vermont, some of the highest rates of mesothelioma have occurred due to the mining of talc and other minerals. Many of the historic buildings on Manhattan and elsewhere throughout the state and nearby states have had to undergo extensive asbestos abatement efforts due to the efforts of Johns and his successors, which has led to the exposure of millions – possibly billions – of people over the years. The asbestos industry itself was born in New York City when Henry Ward Johns, founder of what later became known as the Johns-Manville Corporation, started to market asbestos-containing materials for use in construction projects as early as the 1850s. New York is a diverse state, with a lot of different industries that have exposed workers, residents, and visitors to asbestos over the years. Asbestos in Workplaces Asbestos Exposure in New York Workplaces
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