5/13/2024 0 Comments Daniel schwartz uconnMultifaceted Macrophage Actions in Diseases The New England Immunology Conference 2022 While compelling evidence has indicated the crucial roles played by epigenetic regulators in both normal developmental control and pathogenesis of diseases, our understanding of the full picture is still in its infancy.Ĭapture Macorphage Actions in Diseases Using Novel Single-Cell Transcriptomics-based algorithms To address the unique challenges in large bio-data analyses, we developed additional computational tools empowered by machine learning algorithms and tailored to biological big data mining (invention, patent pending). Notedly, the application of these novel algorithms revealed a hitherto unknown pathogenic foaming program directly associated with the incidence of ASCVD, which enabled the development of a high-performance, proof-of-concept CVD risk prediction model ( Circulation, 2022). Insight, 2019 Mol Cell, 2019, Cell Metabolism, 2022) and immune cell-function guided predictive tools for immunotherapy ( J.E.M., 2021). Our group recently developed new bioinformatics programs that incorporated single-cell transcriptome technology to allow in-depth fine-mapping monocyte/macrophage function under various diseases conditions ( J.C.I. Work from my lab has contributed to the first discovery of miR-150 as a potent regulator for hematopoietic stem cell-derived B-cell formation and function under normal, obese, and cancerous transformation conditions ( PNAS, 2007 Mol Cancer Res, 2013 Sci Report, 2016) and miR-223 as a potent regulator of macrophage polarization ( Circulation, 2012 J.C.I. We have identified several critical regulators in controlling immune lineage determination, cancerous transformation, and their interaction with host tissue cells under chronic stress conditions. My research program focuses on understanding the regulatory mechanisms of immune cells in obesity-induced type 2 diabetes (T2DM) and atherosclerotic cardiovascular diseases (ASCVD). It is the essence of Immunology to capture and harness the actions of immune cells in complex tissue and stress settings is the essence of immunology. Immune cells are often presented with diversified origins/residences and execute multifaceted functions ever-adapting to microenvironmental cues. (Immunology and computational immunology) Research Travel Award, the Graduate School and Office of the Vice President GrantĬlick the link above (Zhou Lab) for more information and meet our members! Research Travel Award, the Graduate School and the Office of the Vice President Grant Travel award, NIH/NIDDK Workshop on microRNA in cellular development and hematopoiesis, Annapolis, Md. Genzyme Fellowship for Postdoctoral Research Women of Innovation 2020 (Research Innovation and Leadership category)Ĭonnecticut Technology Council and Connecticut Center for Advanced TechnoloĬollege of Veterinary Medicine & Biomedical Sciences, Texas A&M University The Connecticut Academy of Science and Engineering Postdoctoral Fellow, Whitehead Institute for Biomedical Research Protein Chemistry and Genetic Engineering College of Life Sciences, Peking University
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